Steffen Mueller

Steffen Mueller is an American virologist and synthetic biologist. He is an Assistant Professor at Stony Brook University in New York.

Mueller received his Ph.D. in molecular microbiology from Stony Brook University in 2002 in the laboratory of Eckard Wimmer.

Mueller is a co-developer of the platform technology dubbed SAVE (Synthetic Attenuated Virus Engineering),[1] a method to produce weakened synthetic viruses that are permanently prevented from regaining virulence.[2]

The method may hold the key to a new class of antiviral, so-called live, or attenuated vaccines.[3][4][5][6][7]

References

  1. ^ Coleman JR, Papamichail D, Skiena S, Futcher B, Wimmer E, Mueller S (2008). "Virus attenuation by genome-scale changes in codon pair bias". Science 320 (5884): 1784–7. doi:10.1126/science.1155761. PMC 2754401. PMID 18583614. http://www.sciencemag.org/cgi/content/full/320/5884/1784. 
  2. ^ Coffin JM (2008). "Attenuation by a thousand cuts". N Engl J Med 359 (21): 2283–5. doi:10.1056/NEJMcibr0805820. PMID 19020330. http://content.nejm.org/cgi/content/extract/359/21/2283. 
  3. ^ Enserink M (2008). "'Biased' viruses suggest new vaccine strategy for polio and other diseases". Science 320 (5884): 1709. doi:10.1126/science.320.5884.1709a. PMID 18583587. http://www.sciencemag.org/cgi/content/full/320/5884/1709a. 
  4. ^ Robinson HL (2008). "Viral attenuation by design". Nat Biotechnol 9 (21): 1000–1. doi:10.1038/nbt0908-1000. PMID 18779812. http://www.nature.com/nbt/journal/v26/n9/full/nbt0908-1000.html. 
  5. ^ "Biased viruses make for good vaccines."
  6. ^ "'Alien code' leads to faster vaccines"
  7. ^ "In the News: Silent mutations cause a stir"

External links